Hyperthermia / Heat Treatment


 
 
 
 
 
What is Hyperthermia?

Hyperthermia ("high temperature") is a form of 'treatment with heat" where a cancerous growth is exposed to high temperatures (over 41.5 oC).

How long has it been in use?

Hippokrates was the first physician to prescribe "psammotherapy' (hot sand bath therapy) for treatment of tumors. It is now well documented that temperatures higher than 41 o C may have lethal effect on cancer cells.

How does Hyperthermia work?

Heat destroys cellular components necessary for the survival and reproduction of the tumor. Cancer cells are more vulnerable to heat than normal cells due to insufficient nutrition and higher acidity. Normal cells have ability to recover from injury to heat.

What are the types of Hyperthermia?

Hyperthermia can be delivered by Ultrasound, Microwaves or Radio-frequency or Laser methods.

How is Hyperthermia delivered?

Hyperthermia is often used in conjunction with radiation and may be used with chemotherpy. Hyperthermia can be delivered non-invasively by external technique by placement of water bag attached to an ultrasound-hyperthermia unit or invasive - interstitial method (placement of catheters in the tissues).
 

What are the conditions treated with Hyperthermia?


Tumors recurrent after initial treatment (cancers of breast, skin -melanoma, enlarged lymph nodes in the neck or axilla, soft tissues etc.)

Why is it used in conjunction with Radiation?

Heated cells are more sensitive to radiation. Heat prevents repair of DNA after radiation. Hyperthermia is the perfect complement to radiation because it is most effective on those cells in which radiation is least effective. (eg: cells deprived of oxygen). Radiation even at very low doses, can yield a better response when combined with hyperthermia. Therefore, patients who received radiation previously can also be candidates for this treatment.

What are the other advantages of Hyperthermia?

Heated cells are more permeable to chemotherapy agents, so that more drug can be taken up by the tumor. Unmasking antigens on the surface of the cancer cells can stimulate immune response.

What are the results from treatment with Hyperthermia and Radiation?

Local control (response) rates of 60-70% (in comparison to 20-30% for radiation alone), are reported for recurrent cancers of various sites by several investigators around the world. In our study at New York Medical College, we also observed similar success.

 
Bone Cancer
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Ewing's Sarcoma
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Myelodyspastic Syndrome
Osteosarcoma
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Address: Department of Radiation Medicine, Zalmen A. Arlin Cancer Institute, Westchester Medical Center, 95 Grasslands Road, Valhalla, NY 10595, Phone: 914-493-8561, Email: info@cancerdocs-radiation.com